Loss of A1 Adenosine Receptor Attenuates Alpha-naphthylisothiocyanate-Induced Cholestatic Liver Injury in Mice
نویسندگان
چکیده
منابع مشابه
Loss of A(1) adenosine receptor attenuates alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.
Cholestasis has limited therapeutic options and is associated with high morbidity and mortality. The A(1) adenosine receptor (A(1)AR) was postulated to participate in the pathogenesis of hepatic fibrosis induced by experimental extrahepatic cholestasis; however, the contribution of A(1)AR to intrahepatic cholestatic liver injury remains unknown. Here, we found that mice lacking A(1)AR were resi...
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James P. Luyendyk, Glenn H. Cantor, Daniel Kirchhofer, Nigel Mackman, Bryan L. Copple, and Ruipeng Wang Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas; Discovery Toxicology, Bristol-Myers Squibb, Princeton, New Jersey; Department of Protein Engineering, Genentech, South San Francisco, California; and Division of Hematology/O...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2012
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfs263